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KMID : 1189420140270010079
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2014 Volume.27 No. 1 p.79 ~ p.90
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Repeated Dose Oral Toxicity Study of Alismatis Rhizoma in SD Rats
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Roh Hang-Sik
Seok Ji-Hyeon
Jeong Ja-Young
Lee Jong-Kwon
Kim Tae-Sung
Choi Hye-Kyung
Ha Hun-Yong
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Abstract
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Objectives : This study was carried out to evaluate the repeated dose oral toxicity of Alismatis Rhizoma in Sprague-Dawley(SD) rats.
Methods : Male and female rats were administered orally with Alismatis Rhizoma water extract of 500 mg/kg(low dosage group), 1,000 mg/kg(middle dosage group) and 2,000 mg/kg(high dosage group). We daily observed number of deaths, clinical signs and gross findings for 14 days(twice a day). After 14 days, we measured body and organs weight. Also we analyzed hematological changes.
Results : No dead SD rats and no clinical signs were found during the experiment period. Also other specific changes were not found between control and treated groups in hematology and serum biochemistry. In addition no significant changes of gross body and individual organs weight.
Conclusions : These results suggest that water soluble extract of Alismatis Rhizoma has not repeated dose oral toxicity and oral LD50 value was over 2,000 mg/kg in SD rats. As a result, we can determine Alismatis Rhizoma is a relatively safe substance.
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KEYWORD
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Repeated, Alismatis Rhizoma, herbal medicine, LD50, SD rat, toxicity
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